Gene information
Official symbol PLA2G7
Official full name phospholipase A2 group VII
Gene type protein-coding gene
Chromosome6p12.3
Alias symbolPAFAH; LDL-PLA2
Gene familyPhospholipases
Resources
Entrez Gene 7941
HGNC HGNC:9040
Ensembl ENSG00000146070
Vega OTTHUMG00000014789
UCSC uc021zae.2
GO terms: 51 records
GO Description Category LogP Number of genes Detail
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0004620 phospholipase activity GO Molecular Functions -8.28406161 12 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0006518 peptide metabolic process GO Biological Processes -2.74792434 15 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0006650 glycerophospholipid metabolic process GO Biological Processes -2.76007072 11 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009395 phospholipid catabolic process GO Biological Processes -2.66946679 4 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0016042 lipid catabolic process GO Biological Processes -9.62855375 20 More
GO:0016298 lipase activity GO Molecular Functions -10.3255371 15 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0016486 peptide hormone processing GO Biological Processes -7.86007212 8 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0030258 lipid modification GO Biological Processes -3.55367288 9 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032994 protein-lipid complex GO Cellular Components -17.0133835 14 More
GO:0034358 plasma lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:0034362 low-density lipoprotein particle GO Cellular Components -6.77353044 5 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034374 low-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0034440 lipid oxidation GO Biological Processes -3.19555965 6 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042445 hormone metabolic process GO Biological Processes -9.53279610 17 More
GO:0043603 cellular amide metabolic process GO Biological Processes -1.84597279 17 More
GO:0044242 cellular lipid catabolic process GO Biological Processes -5.52561510 12 More
GO:0046434 organophosphate catabolic process GO Biological Processes -3.27961839 8 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046503 glycerolipid catabolic process GO Biological Processes -7.85666327 9 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0052689 carboxylic ester hydrolase activity GO Molecular Functions -5.71815649 11 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0140448 signaling receptor ligand precursor processing GO Biological Processes -9.03552172 9 More
GO:1990777 lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
darapladib inhibitor TdgClinicalTrialChemblInteractions view
epoetin beta NCI 16421163 view
rilapladib inhibitor ChemblInteractionsTTD view
Related studies: 17 records
Molecular factor Omics type Application Objective MI type Reference
NM_005084.4:c.835G>T genomics myocardial infarction[diagnosis] myocardial infarction Yamada Y et al. Metabolism. 1998
NM_005084.4:c.1136T>C genomics myocardial infarction[diagnosis] myocardial infarction Abuzeid AM et al. Atherosclerosis. 2003
NM_005084.4:c.1136T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Liu PY et al. J Thromb Haemost. 2006
NM_005084.4:c.835G>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Cahyaningtias M et al. Genes Dis. 2016
NM_005084.4:c.28400C>G genomics myocardial infarction[diagnosis] myocardial infarction Zhang MM et al. Eur Rev Med Pharmacol Sci. 2019
NC_000006.12:g.[46736602C>T;46735776A>G;46735073A>G;46716485C>T;46711566A>G;46709361C>A;46705206A>G] genomics myocardial infarction[diagnosis] myocardial infarction Hou L et al. Hum Genet. 2009
platelet-activating factor acetylhydrolase proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Serebruany VL et al. Cardiology. 1998
platelet-activating factor acetylhydrolase proteomics death[prognosis (bad)] acute myocardial infarction Gerber Y et al. Arterioscler Thromb Vasc Biol. 2006
platelet-activating factor acetylhydrolase proteomics medium predictor major adverse cardiovascular events[prognosis (bad)] anterior ST elevation myocardial infarction Stankovic S et al. Clin Lab. 2012
platelet-activating factor acetylhydrolase proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Dullaart RP et al. Clin Chim Acta. 2013
platelet-activating factor acetylhydrolase proteomics high thrombus burden[prognosis (bad)] acute ST elevation myocardial infarction Wu X et al. Int Heart J. 2016
platelet-activating factor acetylhydrolase proteomics thrombus aspiration[treatment (surgery)] acute ST elevation myocardial infarction Chen BF et al. Acta Cardiol Sin. 2018
platelet-activating factor acetylhydrolase proteomics myocardial infarction[diagnosis] myocardial infarction Zhang MM et al. Eur Rev Med Pharmacol Sci. 2019
platelet-activating factor acetylhydrolase proteomics good predictor coronary slow flow phenomenon[prognosis (bad)] acute myocardial infarction Liang Q et al. Curr Probl Cardiol. 2021
platelet-activating factor acetylhydrolase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Zhang H et al. BMC Cardiovasc Disord. 2020
platelet-activating factor acetylhydrolase proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Wei P et al. Clin Transl Sci. 2020
NC_000006.12:g.46736602C>T genomics myocardial infarction[diagnosis] myocardial infarction Hou L et al. Hum Genet. 2009
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